Mathematical Modelling of Antibiotic Biosynthesis Kinetics and its Relevance to the Process Design and Optimization

Marijan Bošnjak and Milan Vampola

PLIVA - Pharmaceutical, Chemical, Food and Cosmetic Industry, Research Institute Zagreb, Croatia

Article history:
Received May 28, 1993
Accepted July 1, 1993

Summary:
The use of mathematical models in describing kinetics of antibiotic production processes is discussed. The special emphasis is given to models with respect to their role in facilitating the understanding, design, optimization and control of microbial processes. The processes of oxytetracycline and erythromycin biosynthesis where analysed applying our own already developed mathematical model. Since the model was found to fit well to experimental data it was applied to simulate the process course of supposed different cultivation conditions. The applied model was found to be convenient for use in finding the way of improved oxytetracycline production and in improving the method of microorganism selection.